Tert-butyl 4-tert-butyl-3-(cyclopropylmethoxy)phenyl carbonate → 4-tert-Butyl-3-(cyclopropylmethoxy)phenol

Participants

Reaction Steps

To a dioxane (10 mL) solution of tert-butyl 4-tert-butyl-3-(cyclopropylmethoxy)phenyl carbonate. (1.42 g, 4.43 mmol) was added 2M hydrochrolic acid (12 ml) at ambient temperature. The stirred mixture was refluxed for 18 hours. The reaction mixture was then quenched with saturated aqueous solution of sodium bicarbonate and then crude products were extracted with ethyl acetate. The organic layer was then washed with brine, dried over sodium sulfate. After filtration to separate solvent and sodium sulfate, the solvent was removed under reduced pressure to give a residue, which was applied to a silica gel chromatography column and eluted with hexane and ethyl acetate (9/1) to furnish 0.44 g (46% yield) of the title compound as a white solid.

Provenance & Evidence