Ethyl bromoacetate → Ethyl [4-tert-butyl-3-(cyclopropylmethoxy)phenoxy]acetate

Participants

Reaction Steps

4-tert-Butyl-3-(cyclopropylmethoxy)phenol (444 mg, 2.0 mmol), sodium hydride (60% in mineral oil) (68 mg, 1.7 mmol) and ethyl bromoacetate (270 II, 2.4 mmol) were treated in the same procedure described in Example 31(c). The crude residue was applied to a silica gel chromatography column and eluted with a volume mixture of hexane and ethyl acetate (19/1 to 9/1) to furnish 463 mg (75% yield) of the title compound as a yellow oil.

Provenance & Evidence