HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Dipropylcarbamoyl)butanoic acid → N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Dipropylcarbamoyl)butanoic acid | HCID 16772901 | — |
| Reactant | (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol Trifluoroacetate | HCID 69869154 | — |
| Product | N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide | HCID 68607391 | — |
Reaction Steps
Following the general procedure of EXAMPLEs 6 and making non-critical variations and using (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol (VIII, EXAMPLE 5) with 5-(dipropylamino)-5-oxopentanoic acid (DX), the title compound is obtained, MH+=534.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214715B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-32fb999b6abe4d31b0b42dd552ed6d86 |
| Source note | uspto-grants-2007_05 |