HCID 10131699, compound → HCID 58802318, compound

HRID 1350951Notes

Reaction equation

HRID 1350951 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:14][C:15](=[O:24])OCC2C=CC=CC=2)[C@H:11]2[CH2:13][O:12]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH3:25][O:26][C:27]1[CH:36]=[C:35]2[C:30]([CH2:31][CH2:32][CH2:33][CH:34]2[NH2:37])=[CH:29][CH:28]=1.[CH2:38]([N:41]([CH2:55][CH2:56][CH3:57])[C:42]([C:44]1[CH:45]=[C:46]([CH:50]=[C:51]([CH2:53]C)[CH:52]=1)C(O)=O)=[O:43])[CH2:39][CH3:40]>>[F:8][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([F:1])[CH:7]=1)[CH2:9][C@H:10]([NH:14][C:15](=[O:24])[C:46]1[CH:50]=[C:51]([CH3:53])[CH:52]=[C:44]([C:42]([N:41]([CH2:38][CH2:39][CH3:40])[CH2:55][CH2:56][CH3:57])=[O:43])[CH:45]=1)[C@H:11]([OH:12])[CH2:13][NH:37][CH:34]1[C:35]2[C:30](=[CH:29][CH:28]=[C:27]([O:26][CH3:25])[CH:36]=2)[CH2:31][CH2:32][CH2:33]1

Participants

4

Reactant 3

HCID 10131699HCID 10131699, compoundHCID 139145927-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 225936423-[(Dipropylamino)carbonyl]-5-Ethylbenzoic Acid

Product 1

HCID 58802318HCID 58802318, compound

Procedure

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V), 7-methoxy-1,2,3,4-tetrahydro-1-naphthalenylamine (VI) and “5-Me-PHTH” (IX), the title compound is obtained, MH+=622.

Sources & evidence

ORD record
ord-296013b987b7482a9a70a80e7183ef10
Source dataset
uspto-grants-2007_05
Patent number
US07214715B2

Reaction notes

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