HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 86585854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-Aminotetralin, (S)- | HCID 7058074 | — |
| Reactant | (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane | HCID 9861019 | — |
| Product | HCID 86585854 | HCID 86585854 | — |
Reaction Steps
A mixture of benzyl (1S)-1-[(2S)-oxiranyl]-2-phenylethylcarbamate (V, 0.22 g, 0.74 mmol), 3-methoxybenzylamine (VI, 0.13 g, 0.92 mmol), and ethanol (2 mL) is stirred at reflux for 2.3 hours and then cooled and concentrated under reduced pressure. The residue is chouromatographed (silica gel; methanol/dichloromethane/ammonium hydroxide, 4/96/trace) to give the title compound, MS m/z at (m+H)+=435.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214715B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0d07b7870207494c8af123d2eb02b577 |
| Source note | uspto-grants-2007_05 |