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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1350978Generated: November 3, 2026

3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid → N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamide

https://huagongshe.com/reaction/1350978

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Carbamoyl-5-dipropylcarbamoyl-benzoic acidHCID 22394891—
Reactant(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol TrifluoroacetateHCID 69869154—
ProductN-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamideHCID 68610888—

Reaction Steps

Following the procedure of CHART P and EXAMPLE 739 and making non-critical variations but using 3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid (IX) and (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]4-phenyl-2-butanol (VIII), the title compound is obtained, HRMS (FAB)=615.3571.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07214715B2
Source datasetuspto-grants-2007_05
ORD IDord-cadd92cb01f049949607194549d3b964
Source noteuspto-grants-2007_05