2,2,2-Trifluoroethanol → HCID 17956302, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of trifluoroethanol (0.1 g) and sodium hydride (60% dispersion in mineral oil, 0.05 g) in tetrahydrofuran (10 mL) was added the product of step (b) (0.5 g) and the reaction was stirred for 24 hours at 20° C. The reaction was quenched by the addition of methanol (5 mL) and the solvent was removed in vacuo. The residue was partitioned between ethyl acetate (50 mL) and water (50 mL). The organic layer was washed with brine (50 mL), dried and the solvent removed in vacuo. Purification by column chromatography on silica gel (Biotage), eluting with 50% ethyl acetate in cyclohexane to give the title compound (0.27 g). LC retention time 3.17 mins Mass spectrum m/z 472 [MNH4+]

Provenance & Evidence