Sodium Hydroxide → HCID 21097637, compound

Participants

Reaction Steps

26.7 g of 4-fluorophenyl diphenylsulfonium trifluoromethanesulfonate was dissolved in 200 g of dichloromethane in a reaction flask, in which the atmosphere was replaced with nitrogen. 200 g of 10 wt % sodium hydroxide aqueous solution and 14.6 g of 3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-7-thiol were added. The mixture was stirred at 30 minutes for room temperature and transferred to a separatory funnel, shaken, and allowed to stand still. The water layer was removed. After the addition of 300 ml of distilled water, the mixture was further shaken and allowed to stand still. The water layer was removed. The resulting dichloromethane solution was dried with anhydrous magnesium sulfate and filtered. After evaporating dichloromethane from the dried solution, the residual liquid was dried under reduced pressure to obtain 25.6 g of [4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-7-ylsulfonyl)phenyl]diphenylsulfonium trifluoromethanesulfonate.

Provenance & Evidence