Acetate → Ethyl 3-(3,4-difluoro-5-hydroxyphenyl)pentanoate

HRID 135107Notes

Reaction equation

HRID 135107 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:10])[c:5]([F:9])[c:6]([OH:8])[cH:7]1.[C:11]([CH:12]=[CH:13][CH2:14][CH3:15])(=[O:16])[O:17][CH2:18][CH3:19].[C:27](#[N:28])[CH2:29][CH3:30].[CH:20]([NH:21][CH:22]([CH3:23])[CH3:24])([CH3:25])[CH3:26].[O-:32][C:33]([CH3:34])=[O:35].[O-:36][C:37]([CH3:38])=[O:39].[Pd+2:31]>>[c:2]1([CH:13]([CH2:12][C:11](=[O:16])[O:17][CH2:18][CH3:19])[CH2:14][CH3:15])[cH:3][c:4]([F:10])[c:5]([F:9])[c:6]([OH:8])[cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 7854PropionitrileHCID 7912DiisopropylamineHCID 102263Ethyl pent-2-enoateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27733075-Bromo-2,3-Difluorophenol

Product 1

HCID 57470578Ethyl 3-(3,4-difluoro-5-hydroxyphenyl)pentanoate

Sources & evidence

ORD record
ord-a262d84d180b4d2f99f4c62d724a348e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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