Carbon tetrabromide → 3-Tert-butyldimethylsilyloxymethylbenzyl bromide

Participants

Reaction Steps

To a solution of (3-tert-butyldimethylsilyloxymethylphenyl)methanol (528 mg) and tetrabromomethane (694 mg) in dichloromethane (10 mL) was added triphenylphosphine (549 mg) at room temperature, and the mixture was stirred for 2 hours. The reaction mixture was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1) to give the title compound (660 mg).

Provenance & Evidence