Aldehydo-D-ribose → HCID 21097916, compound

HRID 1351117Notes

Reaction equation

HRID 1351117 reaction equation
O=C[C@@H]([C@@H]([C@@H](CO)O)O)O.[OH:11][C@@:12]1([C:19]#[C:20][C:21]2[N:22]=[C:23]([NH:39][CH:40]([CH2:43][CH3:44])[CH2:41][CH3:42])[C:24]3[N:25]=[CH:26][N:27]([C:37]=3[N:38]=2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)[CH2:17][CH2:16][CH2:15][C@@H:14]([CH3:18])[CH2:13]1>>[OH:11][C@@:12]1([C:19]#[C:20][C:21]2[N:38]=[C:37]3[C:24]([NH:25][CH:26]=[N:27]3)=[C:23]([NH:39][CH:40]([CH2:41][CH3:42])[CH2:43][CH3:44])[N:22]=2)[CH2:17][CH2:16][CH2:15][C@@H:14]([CH3:18])[CH2:13]1

Participants

3

Reactant 2

HCID 5311110Aldehydo-D-riboseHCID 21097917HCID 21097917, compound

Product 1

HCID 21097916HCID 21097916, compound

Procedure

Using the representative procedure for ribose cleavage above 2-{2-[1(S)-hydroxy-3(R)-methyl-1-cyclohexyl]ethyn-1-yl}-N6-(3-pentyl)adenosine (1.03 g) gave the product as a white solid: yield 0.725 g, 98%. LRMS ESI (M+H+) 342.2.

Sources & evidence

ORD record
ord-b40bd03e25fd4c79ac25e62f15f292fb
Source dataset
uspto-grants-2007_05
Patent number
US07217702B2

Reaction notes

Loading…