化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → (S)-4-(Oxiran-2-ylmethoxy)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Cyanophenol | HCID 13019 | — |
| 反応物 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (S)-4-(Oxiran-2-ylmethoxy)benzonitrile | HCID 6934187 | 90% |
反応手順
Potassium carbonate (414 g) and (R)-(−)-epichlorohydrin (800 mL) were added to a stirred solution of p-cyanophenol (238 g) in 2.0 L MeCN and the reaction mixture was refluxed under an inert atmosphere for 2 h. The hot solution was filtered and the filtrate concentrated, giving a clear oil which was crystallised from di-iso-propyl ether giving the product in 90% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07217708B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-9d2b0a90311b4c498207674409127ae6 |
| 出典メモ | uspto-grants-2007_05 |