4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → HCID 21098050, compound

HRID 1351155Notes

Reaction equation

HRID 1351155 reaction equation
Cl[C:2]1[C:10]2[C:5](=[N:6][C:7]([NH:11][CH2:12][CH2:13][O:14][CH3:15])=[N:8][CH:9]=2)[N:4]([CH3:16])[N:3]=1.CC1(C)C(C)(C)OB([C:25]2[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=2)O1>>[NH2:29][C:28]1[CH:30]=[CH:31][C:25]([C:2]2[C:10]3[C:5](=[N:6][C:7]([NH:11][CH2:12][CH2:13][O:14][CH3:15])=[N:8][CH:9]=3)[N:4]([CH3:16])[N:3]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 21098059HCID 21098059, compound

Product 1

HCID 21098050HCID 21098050, compound

Procedure

Prepared as described above in Example 15 starting from (3-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-(2-methoxy-ethyl)-amine and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline to give the title compound [3-(4-amino-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-methoxy-ethyl)-amine; LC/MS (m/e)=299.0 (MH+), Rt=1.42 min.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6c3eefc9405b4b5c8dcccd8172fad808
Source dataset
uspto-grants-2007_05
Patent number
US07217710B2

Reaction notes

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