HCID 21098060, compound → HCID 68978662, compound

HRID 1351158Notes

Reaction equation

HRID 1351158 reaction equation
Cl[C:2]1[C:10]2[C:5](=[N:6][C:7]([NH:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[N:8][CH:9]=2)[N:4]([CH3:20])[N:3]=1.[C:21]([O:25][C:26](=[O:44])[NH:27][C:28]1[CH:33]=[CH:32][C:31](B2OC(C)(C)C(C)(C)O2)=[CH:30][C:29]=1[CH3:43])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26](=[O:44])[NH:27][C:28]1[CH:33]=[CH:32][C:31]([C:2]2[C:10]3[C:5](=[N:6][C:7]([NH:11][CH2:12][CH2:13][N:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)=[N:8][CH:9]=3)[N:4]([CH3:20])[N:3]=2)=[CH:30][C:29]=1[CH3:43])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 21098060HCID 21098060, compoundHCID 53217256tert-Butyl [2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

Product 1

HCID 68978662HCID 68978662, compound

Procedure

Prepared as described above in Example 15 starting from (3-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-(2-morpholin-4-yl-ethyl)-amine and [2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester to give the title compound {2-methyl-4-[1-methyl-6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-phenyl}-carbamic acid tert-butyl ester; LC/MS (m/e)=468.2 (MH+), Rt=1.40 min

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ad631bc81fff470b9eb8afb0b4c80ff1
Source dataset
uspto-grants-2007_05
Patent number
US07217710B2

Reaction notes

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