HCID 68981620, compound → HCID 21098067, compound

Participants

Reaction Steps

[4-(6-Methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]carbamic acid tert-butyl ester (1.49 g, 3.70 mmol) was treated with TFA (30% in CH2Cl2, 40 ml) at room temperature for 1 hr. Solvent was removed on rotavap and the residual was taken into 5% Na2CO3 (50 ml) and the product was extracted by CH2Cl2×10, the organic extracts were combined and washed by brine, drying and concentration left 750 mg as a light brown solid; LC/MS(m/e)=304 (MH+).

Provenance & Evidence