Acetic Anhydride → HCID 11232440, compound

Participants

Reaction Steps

A solution of 6,7-dimethoxy-N4-phenyl-quinazoline-4,5-diamine (60 mg, 0.20 mmol) (from Example 1, Step C, supra) in acetic anhydride (2 mL) was heated at 150° C. for 2 hours. Aqueous NaOH solution was then added to the reaction mixture to a pH 10–12. The solution was diluted with chloroform (50 mL). The organic layer was separated, dried over Na2SO4, and concentrated. The residue was purified by chromatography using EtOAc/Et3N (1:0.04) as eluent to give the desired 8,9-dimethoxy-2-methyl-3-phenyl-3H-1,3,4,6-tetraaza-phenalene as a yellow solid. (Yield 20 mg, 62%).

Provenance & Evidence