Sodium Hydroxide → HCID 11221316, compound

Participants

Reaction Steps

A solution of 6,7-dimethoxy-N4-phenyl-quinazoline-4,5-diamine (130 mg, 0.44 mmol) (from Example 1, Step C, supra) in propionic anhydride (3 mL) (Aldrich) was heated at 170° C. for 2 hours. Aqueous NaOH solution was added to the reaction mixture to a pH 10–12. The solution was diluted with chloroform (50 mL). The organic layer was separated, dried over Na2SO4, and concentrated. This residue was purified by chromatography using EtOAc/Et3N (1:0.05) as eluent to give the desired 2-ethyl-8,9-dimethoxy-3-phenyl-3H-1,3,4,6-tetraaza-phenalene as an orange solid. (Yield 21 mg, 14%).

Provenance & Evidence