1,1'-Carbonyldiimidazole → HCID 178486836, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N4-(3-chloro-phenyl)-6,7-dimethoxy-quinazoline-4,5-diamine (80 mg, 0.24 mmol) (from Example 11, Step B, supra) in 1,2-dichloroethane (30 mL) was added 1,1′-carbonyldiimidazole (0.2 g, 1.21 mmol) (Aldrich). The reaction mixture was heated with stirring at 90° C. for 4 hours. The solvents were evaporated and the residue was purified by chromatography using EtOAc/CH2Cl2/Et3N (1:1:0.05) as eluent to give the desired 3-(3-chloro-phenyl)-8,9-dimethoxy-1H,3H-1,3,4,6-tetraaza-phenalen-2-one as a brown solid. (Yield 50 mg, 58%).

Provenance & Evidence