Acetic Anhydride → HCID 11439653, compound

Participants

Reaction Steps

A solution of N4-(3-chloro-phenyl)-6,7-dimethoxy-quinazoline-4,5-diamine (0.2 g, 0.60 mmol) (from Example 11, Step B supra) in acetic anhydride (3 mL) was heated at 150° C. for 2 hours. Aqueous NaOH solution was added to the reaction mixture to a pH 10–12. The solution was extracted with chloroform (50 mL). The organic layer was separated, dried over Na2SO4, and concentrated. The residue was purified by chromatography using EtOAc/CH2Cl2/Et3N (1:1:0.05) as eluent to give the desired 3-(3-chloro-phenyl)-8,9-dimethoxy-2-methyl-3H-1,3,4,6-tetraaza-phenalene as a yellow solid. (Yield 90 mg, 42%).

Provenance & Evidence