Formic Acid → HCID 11336764, compound

Participants

Reaction Steps

A solution of N4-(4-chloro-phenyl)-6,7-dimethoxy-quinazoline-4,5-diamine (160 mg, 0.48 mmol) (from Example 13, Step B, supra) in formic acid (2 mL) was heated at 110° C. for 2 hours. Aqueous NaOH solution was added to the reaction mixture to a pH 10–12. The solution was diluted with chloroform (100 mL). The organic layer was separated, dried over Na2SO4, and concentrated. This residue was purified by chromatography using EtOAc/Et3N (1:0.05) as eluent to give the desired 3-(4-chloro-phenyl)-8,9-dimethoxy-3H-1,3,4,6-tetraaza-phenalene as an off white solid. (Yield 96 mg, 59%).

Provenance & Evidence