Ammonium Hydroxide → 7-Methoxy-4-phenylamino-quinazolin-6-ol

Participants

Reaction Steps

To a solution of 6-acetoxy-7-methoxy-4-phenylamino-quinazoline (1.01 g, 3.27 mmol) (from Example 15, Step A, supra) in MeOH (30 mL) was added an aqueous solution of NH4OH (29%, 2.0 g, 31.4 mmol). The reaction mixture was stirred at room temperature for 18 hours, and then heated at 100° C. for 1.5 hours. The mixture was then cooled to room temperature and filtered. The precipitate was collected and dried in vacuo to give the desired 7-methoxy-4-phenylamino-quinazolin-6-ol as a white solid. (Yield 0.6 g, 69%).

Provenance & Evidence