Ammonium Hydroxide → HCID 21098391, compound

Participants

Reaction Steps

To a solution of 6-acetoxy-4-(4-chloro-phenylamino)-7-methoxy-quinazoline (1.4 g, 4.07 mmol) (from Example 16, Step A, supra) in MeOH (35 mL) was added an aqueous solution of NH4OH (29%, 0.82 mL, 12.2 mmol). The reaction mixture was stirred at room temperature for 18 hours, then heated at 100° C. for 1.5 hours. The mixture was then cooled to room temperature and filtered. The precipitate was collected and dried in vacuo to give the desired 4-(4-chloro-phenylamino)-7-methoxy-quinazolin-6-ol as a gray solid. (Yield 0.67 g, 55%).

Provenance & Evidence