Ammonium Hydroxide → 4-((4-Bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

Participants

Reaction Steps

To a solution of 6-acetoxy-4-(4-bromo-2-fluoro-phenylamino)-7-methoxy-quinazoline (1.36 g, 3.34 mmol) (from Example 19, Step A, supra) in MeOH (30 mL) was added an aqueous solution of NH4OH (29%, 0.68 mL, 10 mmol). The reaction mixture was stirred at room temperature for 18 hours, then heated at 100° C. for 1.5 hours. The mixture was then cooled to room temperature and filtered. The precipitate was collected and dried in vacuo to give the desired 4-(4-bromo-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-ol as a gray solid. (Yield 0.93 g, 77%).

Provenance & Evidence