tert-Butanol → HCID 69416176, compound

Participants

Reaction Steps

7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid (18 g), 15.3 mL of triethylamine (15.3 mL) and 30.3 g of diphenylphosphoryl azide (30.3 g) in t-butyl alcohol (360 mL) were heat refluxed for 1 hour. After the organic solvent was removed by evaporation at reduced pressure, purification by NH silica gel column chromatography was carried out. Recrystallization from dichloromethane-hexane was carried out to provide the title compound (19.1 g) as a colorless crystal.

Provenance & Evidence