Hydrogen chloride-ethyl acetate → HCID 21098612, compound

HRID 1351245Notes

Reaction equation

HRID 1351245 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]2[CH2:16][CH2:15][CH2:14][C:13](=[O:17])[C:10]=2[S:11][CH:12]=1)(C)(C)C.[ClH:19].C(OCC)(=O)C>>[ClH:19].[NH2:7][C:8]1[C:9]2[CH2:16][CH2:15][CH2:14][C:13](=[O:17])[C:10]=2[S:11][CH:12]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69416176HCID 69416176, compound

Product 1

HCID 21098612HCID 21098612, compound

Procedure

(7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-yl)-carbamic acid t-butyl ester (18.9 g) in 4N hydrochloric acid/ethyl acetate (200 mL) was stirred for 1 hour. The resulting solid was collected by filtration, washed with ethyl acetate to provide the title compound (13.9 g) as an off-white solid.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-a7163694d4ca4bc093d1e894e11af7f5
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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