Benzyl-methyl-(2-pyridine-3-yl-ethyl-)amine → N-Methyl-2-(pyridin-3-YL)ethanamine

HRID 1351251ノート

反応式

HRID 1351251 の反応式
[CH2:1]([N:8](C)[CH2:9][CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:1][NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 21098723Benzyl-methyl-(2-pyridine-3-yl-ethyl-)amine

生成物 1

HCID 5152594N-Methyl-2-(pyridin-3-YL)ethanamine収率 92.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of benzyl-methyl-(2-pyridine-3-yl-ethyl-)amine (4.3 g) in methanol was added 10% palladium-carbon, and was stirred at 50° C. under hydrogen atmosphere for 1 hour. After filtrating with Celite, the filtrate was concentrated, and the title compound (2.39 g) was obtained as a colorless oily matter.

後処理

  1. filtrationAfter filtrating with Celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-53834a53e55845ba88056155291c8af4
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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