Hydrogen chloride-ethyl acetate → [2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

Participants

Reaction Steps

To a solution of [2-(4-fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester (506 mg) in ethyl acetate (2 mL) was added a solution of 4N hydrochloric acid-ethyl acetate (2 mL) at room temperature and allowed to stand for 2.5 hours. The resulting solid was diluted with diethyl ether, then filtered, and washed with diethyl ether. After drying by aeration, the title compound (338 mg) was obtained as a colorless solid.

Provenance & Evidence