4-Phenylpiperidin-4-ol → 3-(4-Hydroxy-4-phenyl-piperidine-1-sulfonyl) 5,6-dihydro-4H-benzo[b]thiophene-7-one

HRID 1351274Notes

Reaction equation

HRID 1351274 reaction equation
[C:1]1([C:7]2([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:14]=[C:15]1[C:20]2[S:21][CH:22]=[C:23]([S:24](Cl)(=[O:26])=[O:25])[C:19]=2[CH2:18][CH2:17][CH2:16]1>>[OH:13][C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:12][CH2:11][N:10]([S:24]([C:23]2[C:19]3[CH2:18][CH2:17][CH2:16][C:15](=[O:14])[C:20]=3[S:21][CH:22]=2)(=[O:25])=[O:26])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 210986093-(4-Hydroxy-4-phenyl-piperidine-1-sulfonyl) 5,6-dihydro-4H-benzo[b]thiophene-7-one

Procedure

From 4-phenyl-piperidine-4-ol (36 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (50 mg), the title compound (72 mg) was obtained as a colorless amorphous substance, in the same way as Preparation Example 41.

Sources & evidence

ORD record
ord-e31d085920ef44e8b608ee17c440e84d
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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