7-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride → HCID 77617953, compound

HRID 1351275Notes

Reaction equation

HRID 1351275 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[CH2:9][NH:10][CH3:11])=[CH:4][CH:3]=1.[O:13]=[C:14]1[C:19]2[S:20][CH:21]=[C:22]([S:23](Cl)(=[O:25])=[O:24])[C:18]=2[CH2:17][CH2:16][CH2:15]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])[CH2:9][N:10]([CH3:11])[S:23]([C:22]2[C:18]3[CH2:17][CH2:16][CH2:15][C:14](=[O:13])[C:19]=3[S:20][CH:21]=2)(=[O:24])=[O:25])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chlorideHCID 219434071-(4-Fluorophenyl)-2-(methylamino)ethan-1-ol

Product 1

HCID 77617953HCID 77617953, compound

Procedure

From 1-(4-fluorophenyl)-2-methylamino-ethanol (the compound of Preparation Example 17) (433 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7), the title compound (769 mg) was obtained as a colorless amorphous substance, in the same way as Preparation Example 41.

Sources & evidence

ORD record
ord-ee43d9cae5b24303b5ab6f0e570f114e
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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