2-Amino-1-(2,4-difluorophenyl)ethan-1-ol hydrochloride → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-amide

HRID 1351278Notes

Reaction equation

HRID 1351278 reaction equation
[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[C:10]([S:11](Cl)(=[O:13])=[O:12])[C:6]=2[CH2:5][CH2:4][CH2:3]1.Cl.[NH2:16][CH2:17][CH:18]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=1[F:27])[OH:19]>>[F:27][C:21]1[CH:22]=[C:23]([F:26])[CH:24]=[CH:25][C:20]=1[CH:18]([OH:19])[CH2:17][NH:16][S:11]([C:10]1[C:6]2[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[C:7]=2[S:8][CH:9]=1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 210985652-Amino-1-(2,4-difluorophenyl)ethan-1-ol hydrochlorideHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 210986777-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-amide

Procedure

From 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (280 mg) and 2-amino-1-(2,4-difluorophenyl)-ethanol hydrochloride (the compound of Preparation Example 20) (281 mg), the title compound (290 mg) was obtained as a colorless solid, in the same way as Preparation Example 41.

Workup

  1. customthe compound of Preparation Example 20) (281 mg)

Sources & evidence

ORD record
ord-33b85ba29a8348e39c9033e6f354fd14
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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