2-Bromo-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride → 2-Bromo-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-amide

HRID 1351282Notes

Reaction equation

HRID 1351282 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[CH2:9][NH:10][CH3:11])=[CH:4][CH:3]=1.[Br:13][C:14]1[S:18][C:17]2[C:19](=[O:23])[CH2:20][CH2:21][CH2:22][C:16]=2[C:15]=1[S:24](Cl)(=[O:26])=[O:25]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])[CH2:9][N:10]([CH3:11])[S:24]([C:15]2[C:16]3[CH2:22][CH2:21][CH2:20][C:19](=[O:23])[C:17]=3[S:18][C:14]=2[Br:13])(=[O:26])=[O:25])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 210985802-Bromo-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chlorideHCID 219434071-(4-Fluorophenyl)-2-(methylamino)ethan-1-ol

Product 1

HCID 210985782-Bromo-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-amide

Procedure

From 1-(4-fluorophenyl)-2-methylamino-ethanol (the compound of Preparation Example 17) (186 mg) and 2-bromo-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 9) (330 mg), the title compound (373 mg) was obtained as a light brown candy-like substance, in the same way as Preparation Example 41.

Workup

  1. customthe compound of Preparation Example 9) (330 mg)

Sources & evidence

ORD record
ord-f95ce56c18a24fcd84e79fa8070a531a
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

Loading…