Sodium borohydride → HCID 21098651, compound

HRID 1351292Notes

Reaction equation

HRID 1351292 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:21])[CH2:9][N:10]([CH3:20])[S:11]([C:14]2[S:15][C:16]([Br:19])=[CH:17][CH:18]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:21])[CH2:9][N:10]([CH3:20])[S:11]([C:14]2[S:15][C:16]([Br:19])=[CH:17][CH:18]=2)(=[O:12])=[O:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 21098653HCID 21098653, compound

Product 1

HCID 21098651HCID 21098651, compoundYield 94%

Procedure

5-bromothiophene-2-sulfonic acid [2-(4-fluorophenyl)-2-oxoethyl]-methyl-amide (270 mg) was reduced with sodium borohydride (26 mg) on an ice-bath and the title compound (255 mg) was obtained as a yellow oily substance.

Sources & evidence

ORD record
ord-5fd3d2ba51e440a2b73cb4b6d7e322db
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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