HCID 69416370, compound → HCID 86600999, compound

Participants

Reaction Steps

From (3-{[2-(4-fluorophenyl)-2-methoxymethoxyethyl]methylsulfamoyl}-5-formylthiophene-2-yl)carbamic acid t-butyl ester (160 mg) and 0.35 mL of a solution (0.35 mL) of 2.0M benzyl magnesium chloride-tetrahydrofuran, [3-{[2-(4-fluorophenyl)-2-methoxymethoxyethyl]methylsulfamoyl}-5-(1-hydroxy-2-phenylethyl)thiophene-2-yl]carbamic acid t-butyl ester was obtained, in the same way as Preparation Example 87. Thereafter, oxidation reaction was carried out, which was the same as Preparation Example 108, and the title compound (47 mg) was obtained as an orange oily substance.

Provenance & Evidence