p-Fluorophenylalanine → HCID 21098608, compound

HRID 1351319Notes

Reaction equation

[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[C:10]([C:11]([OH:13])=O)[C:6]=2[CH2:5][CH2:4][CH2:3]1.[CH:14]1[C:19]([CH2:20][CH:21]([NH2:25])[C:22]([OH:24])=[O:23])=[CH:18][CH:17]=[C:16]([F:26])[CH:15]=1>>[F:26][C:16]1[CH:15]=[CH:14][C:19]([CH2:20][CH:21]([NH:25][C:11]([C:10]2[C:6]3[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[C:7]=3[S:8][CH:9]=2)=[O:13])[C:22]([OH:24])=[O:23])=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 4654p-Fluorophenylalanine

HCID 3860983STK279704

Product 1

HCID 21098608HCID 21098608, compound

Procedure

From 7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (the compound of Preparation Example 4) (105 mg) and DL-4-fluorophenylalanine, the title compound (190 mg) was obtained as a viscous yellow oily substance, in the same way as Preparation Example 116.

Sources & evidence

ORD record: ord-cf0c10269e0a4e1b86ee80f65e9b4e10
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07217723B2

Reaction notes

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