(2-(4-Fluorophenyl)ethyl)(methyl)amine → HCID 21098650, compound

HRID 1351323Notes

Reaction equation

HRID 1351323 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][NH:19][CH3:20])=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][N:19]([CH3:20])[C:7]([C:5]2[S:6][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:9])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 120234(2-(4-Fluorophenyl)ethyl)(methyl)amineHCID 3491155-Bromothiophene-2-carboxylic acid

Product 1

HCID 21098650HCID 21098650, compound

Procedure

From 5-bromo-thiophene-2-carboxylic acid (1.0 g) and [2-(4-fluorophenyl)-ethyl]-methyl-amine (the compound of Preparation Example 14) (740 mg), a colorless solid (1.39 g) was obtained, in the same way as Preparation Example 118-b).

Sources & evidence

ORD record
ord-d3a6feac090849d7acf14d98cddb8b64
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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