Trifluoroacetic acid methylene chloride → HCID 17961816, compound

HRID 1351352Notes

Reaction equation

HRID 1351352 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([O:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:9]([OH:20])[N:8]=[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][N:22]2C(OC(C)(C)C)=O)[N:6]=1)=[O:4].[C:33](O)(C(F)(F)F)=O.C(Cl)Cl>>[C:12]([O:11][C:10]1[C:9](=[O:20])[N:8]([CH3:33])[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)=[N:6][C:5]=1[C:3]([O:2][CH3:1])=[O:4])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 178499071HCID 178499071, compound

Product 1

HCID 17961816HCID 17961816, compound

Procedure

Methyl-5-(benzoyloxy)-2-[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-6-hydroxypyrimidine-4-carboxylate was treated with TFA:CH2Cl2 (3:7) at 0° C. The solution was warmed to room temperature and the progress of the reaction was monitored by MS analysis. After 1 h the reaction was complete and the solvent was removed under reduced pressure using a rotatory evaporator. The title product was precipitated with Et2O and collected by filtration.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customa rotatory evaporator
  3. customThe title product was precipitated with Et2O
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-269993090db3463295f1774d71a7df5b
Source dataset
uspto-grants-2007_05
Patent number
US07217713B2

Reaction notes

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