Acetonitrile → 3-[[1-(5-Chloro-2-pyridinyl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]amino]-1,1,1-trifluoropropan-2-ol

HRID 135140Notes

Reaction equation

HRID 135140 reaction equation
[CH3:35][C:36]#[N:37].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)([NH2:16])[c:17]2[cH:18][c:19]([F:27])[cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[n:6][cH:7]1.[F:28][C:29]([CH:30]1[O:31][CH2:32]1)([F:33])[F:34]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)([NH:16][CH2:32][CH:30]([C:29]([F:28])([F:33])[F:34])[OH:31])[c:17]2[cH:18][c:19]([F:27])[cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]2)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 5207692-(Trifluoromethyl)oxiraneHCID 591345731-(5-Chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Product 1

HCID 724631843-[[1-(5-Chloro-2-pyridinyl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]amino]-1,1,1-trifluoropropan-2-ol

Sources & evidence

ORD record
ord-b20b7d005d30441493f6ab6a75c41acf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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