HCID 69040941, compound → HCID 69039275, compound

HRID 1351422Notes

Reaction equation

[ClH:1].Cl.[N+](OC[CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:41])[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18](=[O:40])[C@H:19]([CH2:35][CH2:36][CH2:37][CH2:38][NH2:39])[NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([O-])=O.Cl.[N+:43]([O:46]CCCOC(=O)[C@@H]1CCCN1)([O-:45])=[O:44]>>[ClH:1].[ClH:1].[N+:43]([O:46][CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:41])[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18](=[O:40])[C@H:19]([CH2:35][CH2:36][CH2:37][CH2:38][NH2:39])[NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([O-:45])=[O:44]

Participants

Reactant 2

HCID 69040941HCID 69040941, compound

HCID 69043023HCID 69043023, compound

Product 1

HCID 69039275HCID 69039275, compound

Procedure

Starting from N2-[(1S)-ethoxycarbonyl-3-phenylpropyl]-N6-BOC-L-lysine (obtained as described in Example 6) and L-proline 3-nitrooxypropyl ester hydrochloride (obtained as described in Example 3) applying the same procedure described in Example 6) the title compound was obtained as a highly hygroscopic white powder (0.85 g, 28%).

Sources & evidence

ORD record: ord-4f7634ae65b84252b89ea846d525a272
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07217733B2

Reaction notes

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