Hexamethylenetetramine → 4-Hydroxy-3,5-bis(isopropyl)benzaldehyde

Participants

Reaction Steps

18 g of 2,6-di isopropyl phenol and 1.8 g HMTA (hexamethylene tetraamine) in 60 ml TFA (trifluoro acetic acid) was refluxed 3.5 hours. Workup, chromatography on silica gel (CH2Cl2) and trituration with hexane gave 5.3 g, 0.26% yield, white solid, mp—103° C. (3,5,-di-iso-propyl 4 hydroxybenzaldehyde). NMR CDCl3 δ 9.87(1H, S, CHO), 7.63(2H, S), 3.19(2H, septet, J=7.7 Hz), 1.30(12H, d, J=7.7 Hz).

Provenance & Evidence