4-Chloro-2-methylthiopyrimidine → 4-Methylbenzyl 4-({[2-(methylsulfanyl)-4-pyrimidinyl]amino}methyl)-1-piperidinecarboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-Chloro-2-methylthiopyrimidine	HCID 97113	—
Reactant	4-Methylbenzyl 4-(aminomethyl)1-piperidinecarboxylate	HCID 16109417	—
Product	4-Methylbenzyl 4-({[2-(methylsulfanyl)-4-pyrimidinyl]amino}methyl)-1-piperidinecarboxylate	HCID 10134767	—

Reaction Steps

The 4-[(2-methylsulfanyl-pyrimidin-4-ylamino)-methyl]-piperidine-1-carboxylic acid 4-methyl-benzyl ester was prepared as described in EXAMPLE 13, Step 2, but replacing 6-chloropurine with 4-chloro-2-methylthiopyrimidine and replacing benzyl 4-(aminomethyl)-1-piperidinecarboxylate with 4-methylbenzyl 4-(aminomethyl)-1-piperidinecarboxylate. M.S. (M+1): 387

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07217716B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-027f13042c464db8b0f2b573d6899787
Source note	uspto-grants-2007_05