Sodium Acetate → HCID 178525134, compound

HRID 1351487Notes

Reaction equation

HRID 1351487 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.C([O-])(=[O:28])C.[Na+]>C(O)(=O)C>[OH:28][C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 10155464HCID 10155464, compound

Product 1

HCID 178525134HCID 178525134, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

Benzyl 4-{[(6-chloro-3-pyridazinyl)amino]methyl}-1-piperidinecarboxylate (EXAMPLE 22) (37 mg, 0.10 mmol) was dissolved in acetic acid (5 mL) with sodium acetate (82 mg, 1.00 mmol) and was heated to 100° C. for 18 h. The volatiles were removed under reduced pressure and the residue partitioned between sat. NaHCO3 and ethyl acetate. The organics were dried over Na2SO4, filtered and concentrated under reduced pressure, affording the title compound as a clear oil.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe residue partitioned between sat. NaHCO3 and ethyl acetate
  3. dry with materialThe organics were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-43a2915f9ee94ba080ce53dba6c17cb8
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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