HCID 10199442, compound → HCID 22135665, compound

HRID 1351519Notes

Reaction equation

HRID 1351519 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]2[C:24]([CH3:25])=[CH:23][N:22]=[C:21](Cl)[N:20]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:25][C:24]1[C:19]([NH:18][CH2:17][CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[N:20][CH:21]=[N:22][CH:23]=1

Participants

4

Reactant 1

HCID 10199442HCID 10199442, compound

Product 1

HCID 22135665HCID 22135665, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[(2-chloro-5-methyl-pyrimidin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester (EXAMPLE 59, 2.00 g, 5.34 mmol), Pd/C (10%, 0.20 g) in absolute ethanol (15 mL) was vigorously stirred under 1 atm H2. Filtered and concentrated, the reaction gave 4-[(5-methyl-pyrimidin-4-ylamino)-methyl]-piperidine. M.S. (M+1): 207.29

Workup

  1. filtrationFiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-51914941ff3d450590821308aa26f505
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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