HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyrimidine → HCID 23577265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzyl 3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 15550581 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 23577265 | HCID 23577265 | — |
Reaction Steps
A mixture of 3-aminomethyl-pyrrolidine-1-carboxylic acid benzyl ester (0.15 g), 2-bromopyrimidine (0.25 g), 2-propanol (10 mL), and of N,N-diisopropylethylamine (0.1 mL) was heated to reflux overnight. Purification of the residue obtained after concentration under reduced pressure by preparative chromatography, and eluting with ethyl acetate, gave 3-(pyrimidin-2-ylaminomethyl)-pyrrolidine-1-carboxylic acid benzyl ester as a solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07217716B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-f3d36f4dbee046f29b15a41ce582d5f3 |
| Source note | uspto-grants-2007_05 |