[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine → HCID 178527406, compound

HRID 1351553Notes

Reaction equation

HRID 1351553 reaction equation
[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:21]1[N:29]=[C:28]2[C:24]([N:25]=[CH:26][NH:27]2)=[CH:23][N:22]=1>>[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:13][CH2:14][CH:15]([CH2:18][NH:19][C:21]3[N:29]=[C:28]4[C:24]([N:25]=[CH:26][NH:27]4)=[CH:23][N:22]=3)[CH2:16][CH2:17]2)(=[O:10])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 22135729[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamineHCID 178478330HCID 178478330, compound

Product 1

HCID 178527406HCID 178527406, compound

Procedure

EXAMPLE 82 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-chloro-9H-purine (2-chloro-9H-purine was prepared according to S. R. Brashears, S. S. Wang, S. G. Bechtolt, B. E. Christensen, J. Am. Chem. Soc., 81:3789–3792(1959)): MS (m+1)=401.

Sources & evidence

ORD record
ord-4987fc91a8be4ff69e963c696829bc23
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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