HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine → [1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrazin-2-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine | HCID 23577245 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | EtOH triethylamine | HCID 22663003 | — |
| Product | [1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrazin-2-yl-amine | HCID 23577294 | — |
Reaction Steps
EXAMPLE 90 was prepared from (3-chloro-pyrazin-2-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine by hydrogenation in ethanol-triethylamine over 5% palladium on carbon, 1 atm of hydrogen: MS (m+1)=361.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07217716B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-f2467d12eead4d1cb847d23e19100e76 |
| Source note | uspto-grants-2007_05 |