2-Chloro-4,5-dimethylpyrimidine → 4-[(4,5-Dimethyl-pyrimidin-2-ylamino)-methyl]-piperidine-1-carboxylic acid 4-methyl-benzyl ester

HRID 1351606Notes

Reaction equation

HRID 1351606 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][N:3]=1.[NH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=2)=[O:19])[CH2:14][CH2:13]1>>[CH3:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][O:20][C:18]([N:15]2[CH2:16][CH2:17][CH:12]([CH2:11][NH:10][C:2]3[N:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][N:3]=3)[CH2:13][CH2:14]2)=[O:19])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 125817842-Chloro-4,5-dimethylpyrimidineHCID 161094174-Methylbenzyl 4-(aminomethyl)1-piperidinecarboxylate

Product 1

HCID 235773034-[(4,5-Dimethyl-pyrimidin-2-ylamino)-methyl]-piperidine-1-carboxylic acid 4-methyl-benzyl ester

Procedure

The title compound was prepared from 2-chloro-4,5-dimethylpyrimidine (EXAMPLE 148, STEP 1) and INTERMEDIATE 2A as described in a manner similar to that described in EXAMPLE 144, STEP 2 to give the title compound. M.S.(M+1): 369

Sources & evidence

ORD record
ord-ddfa7bd939924953a701f83520203473
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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