[(E)-2-(2,4-difluorophenyl)ethenyl]boronic acid → Methyl 2-({4-[(E)-2-(2,4-difluorophenyl)vinyl]phenyl}sulfonyl)benzoate

Participants

Reaction Steps

The title compound was prepared according to the method described in Example 138, Step 3 using methyl 2-[(4-bromophenyl)sulfonyl]benzoate (Step 1) in place of (1S)-1-[2-({4-bromo-3-methylphenyl}sulfonyl)phenyl]ethanol and [(E)-2-(2,4-difluorophenyl)vinyl]boronic acid (Step 2) in place of [(E)-2-(4-fluorophenyl)vinyl]boronic acid. δH (500 MHz, d6 DMSO): 8.22–8.20 (1H, m), 7.94–7.80 (7H, m), 7.69–7.63 (1H, m), 7.44 (1H, d, J 16.4), 7.39 (1H, d, J 16.4), 7.35–7.30 (1H, m), 7.19–7.15 (1H, m), 3.87 (3H, s). m/z (ES+) 383 [(M−MeO)+].

Provenance & Evidence