3-Iodophthalic acid → 3-Iodophthalic anhydride

HRID 1351699Notes

Reaction equation

HRID 1351699 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:11]([OH:13])=[O:12]>C(OC(=O)C)(=O)C>[I:1][C:2]1[C:3]2[C:11](=[O:12])[O:13][C:5](=[O:7])[C:4]=2[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 1

HCID 2382313-Iodophthalic acid

Product 1

HCID 2820713-Iodophthalic anhydrideYield 65.2%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 3-iodophthalic acid (0.9 g, 3.08 mmol) in acetic anhydride (5 mL) was heated to reflux under nitrogen overnight. After cooling, the solvent was removed in vacuo and the residue purified by trituration with ethanol to give 4-iodo-2-benzofuran-1,3-dione (0.55 g, 65%).

Workup

  1. temperatureto reflux under nitrogen overnight
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo
  4. customthe residue purified by trituration with ethanol

Sources & evidence

ORD record
ord-4318fe1b7da8414a98ba2ac85f02026d
Source dataset
uspto-grants-2007_05
Patent number
US07217740B2

Reaction notes

Loading…