Malonic Acid → HCID 11172599, compound

Participants

Reaction Steps

Malonic acid (40 g, 0.38 mol) and neopentyl alcohol (77.5 g, 0.88 mol) are refluxed for 3 hours in 110 ml of toluene in the presence of 0.2 ml of concentrated sulfuric acid in a reactor equipped with Dean-Stark apparatus. The water formed is removed azeotropically. The organic phase is washed 3 times with water and dried over sodium sulfate. After filtration and evaporation of the solvent under vacuum, 88 g (94% yield) of dineopentyl malonate are obtained in the form of a colorless oil, and are used in the next step without further purification.

Provenance & Evidence