Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- | HCID 117439 | — |
| Reactant | Sodium methanolate methanol | HCID 23694274 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21099669 | HCID 21099669 | 93% |
Reaction Steps
To a solution of N-Boc-tyrosine (281 mg, 1.0 mmol) in methanol (0.5 mL) were added 28% sodium methoxide-methanol solution (0.8 mL, 4.0 mmol) and 2-picolyl chloride hydrochloride (230 mg, 1.4 mmol), and the mixture was stirred at 25° C. for 24 hr. Then, water (3 mL) was added make the system homogeneous, which system was then analyzed by HPLC. As a result, the objective N-Boc-(O-2-picolyl)tyrosine (346 mg, conversion yield 93%) was confirmed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07217835B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-4079e3bb45bc4593a4e32b9f76cca6a7 |
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| Source note | uspto-grants-2007_05 |
|---|
